Across TCGA patient cohorts, HES4 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,293 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HES4-associated proteins across cancer lineages are CLINT1, LRRC25, and NAXE. Each is linked with HES4 in more than 3 cancer types. Because this analysis shows association rather than direction, both HES4-to-partner and partner-to-HES4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HES4→partner) and Y-score (partner→HES4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CLINT1 →	-0.165	-0.666	<.001	<.001	3	4
UCEC	LRRC25 →	-0.532	-1.277	<.001	<.001	3	3
OV	NAXE →	-0.492	-1.113	.001	<.001	3	3
OV	NHP2 →	-0.331	-0.819	<.001	<.001	3	3
LUAD	MARCKSL1_S22 →	+1.102	+0.715	.001	.002	3	3
OV	MCCC1 →	-0.587	-1.384	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,293 associations by consensus.

Exploration

HES4 survival (RNA) · tumor vs normal (RNA) · all HES4 data types