Across TCGA patient cohorts, HES4 protein abundance is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HES4-associated genes across cancer lineages are SYDE1, CD69, and LDHB. Each is linked with HES4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HES4-to-partner and partner-to-HES4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HES4→partner) and Y-score (partner→HES4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYDE1 →	-0.639	-1.179	.009	<.001	3	1
UCEC	CD69 →	-1.839	-2.370	.003	.004	3	1
UCEC	LDHB →	-1.208	-1.615	.007	.002	3	1
UCEC	PRPH2 →	-0.644	-1.618	.009	<.001	3	1
UCEC	TPSG1 →	-0.520	-2.044	.007	.005	3	1
UCEC	FAM209A →	-0.515	-1.359	.008	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Exploration

HES4 survival (RNA) · tumor vs normal (RNA) · all HES4 data types