Across TCGA patient cohorts, HES4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible HES4-associated genes across cancer lineages are RNU6-147P, MIR1224, and GNAI2P2. Each is linked with HES4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HES4-to-partner and partner-to-HES4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HES4→partner) and Y-score (partner→HES4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-147P →	+0.371	+5.812	<.001	.003	3	1
CESC	MIR1224 →	+0.714	+6.342	<.001	.001	3	1
CESC	GNAI2P2 →	+0.043	+5.306	<.001	.006	3	1
LUAD	RNU6-289P →	+0.193	+7.930	<.001	.008	3	1
LUAD	RNU4-66P →	+0.148	+7.930	<.001	.008	3	1
LUAD	HNRNPDP2 →	+0.044	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

HES4 survival (RNA) · tumor vs normal (RNA) · all HES4 data types