Across TCGA cell cohorts, HES4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,623 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible HES4-associated GO terms across cancer lineages are Regulation of pattern recognition receptor signaling pathway, Negative regulation of cytoplasmic pattern recognition receptor signaling pathway, and Positive regulation of striated muscle contraction. Each is linked with HES4 in more than 10 cancer types. Because this analysis shows association rather than direction, both HES4-to-partner and partner-to-HES4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HES4→partner) and Y-score (partner→HES4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of pattern recognition receptor signaling pathway →	+0.083	+1.691	<.001	<.001	3	11
OESOPHAGUS	Negative regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.118	+2.190	.005	<.001	2	10
PANCREAS	Positive regulation of striated muscle contraction →	-0.241	-1.177	<.001	.007	3	9
LARGE_INTESTINE	Cell-substrate junction assembly →	+0.133	+0.984	<.001	.001	3	9
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.135	+1.505	.004	.003	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to endoplasmic reticulum →	+0.113	+1.250	.003	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,623 associations by consensus.

Exploration

HES4 survival (RNA) · tumor vs normal (RNA) · all HES4 data types