Across TCGA cell cohorts, HES4 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HES4-associated genes across cancer lineages are ACER1 and CT45A2. Each is linked with HES4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HES4-to-partner and partner-to-HES4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HES4→partner) and Y-score (partner→HES4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.092	+3.823	.002	.006	3	1
LARGE_INTESTINE	CT45A2 →	+0.021	+4.054	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Exploration

HES4 survival (RNA) · tumor vs normal (RNA) · all HES4 data types