HES2

Across TCGA pan-cancer cohorts, HES2 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated HES2 data layer compared with 21 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HES2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HES2 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC are the cancer types where HES2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.525	0.292	.010	11	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

HES2–PDAC (DFS)

Open the PDAC breakdown →