HES1

Across TCGA pan-cancer cohorts, HES1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HES1 data layer compared with 20 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HES1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HES1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, BRCA, and BLCA are the cancer types where HES1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.069	0.768	<.001	24	view →
BRCA	OS	Median	All	0.113	0.578	.013	18	view →
BLCA	OS	Median	IV	0.096	0.594	<.001	18	view →
COAD	OS	Median	All	0.500	0.869	.010	12	view →
UCEC	DFS	Median	All	1.000	0.625	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HES1–HNSC (OS)

Open the HNSC breakdown →