HES1

Across TCGA patient cohorts, HES1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,335 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HES1-associated genes across cancer lineages are FCGR3B, CXCR1, and CXCL1. Each is linked with HES1 in more than 5 cancer types. Because this analysis shows association rather than direction, both HES1-to-partner and partner-to-HES1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HES1 versus FCGR3B in PDAC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HES1→partner) and Y-score (partner→HES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FCGR3B →	+2.115	+1.282	<.001	<.001	3	6
LUAD	CXCR1 →	+0.806	+0.950	.001	<.001	3	5
UCEC	CXCL1 →	+2.568	+0.700	<.001	<.001	3	5
PDAC	CXCR2 →	+1.454	+1.155	<.001	<.001	3	5
UCEC	S100A8 →	+1.799	+0.470	<.001	<.001	3	4
PDAC	CXCL5 →	+2.830	+1.041	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,335 associations by consensus.

HES1 vs FCGR3B — PDAC

Explore this scatter interactively →