HES1

Across TCGA patient cohorts, HES1 mutation is significantly associated with the RNA expression of many other genes, with 770 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HES1-associated genes across cancer lineages are OR51V1, RNA5SP222, and FBXL12P1. Each is linked with HES1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HES1-to-partner and partner-to-HES1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51V1 grouped by HES1-low versus HES1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HES1→partner) and Y-score (partner→HES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR51V1 →	+0.057	+5.307	<.001	.001	3	2
BRCA	RNA5SP222 →	+0.231	+7.731	<.001	.009	3	2
BLCA	FBXL12P1 →	+0.036	+4.147	<.001	.009	3	2
UCEC	RNA5SP176 →	+0.559	+4.370	<.001	<.001	3	2
UCEC	RNA5SP213 →	+0.840	+3.249	<.001	.005	3	2
SKCM	ALDH7A1P4 →	+0.289	+6.993	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 770 associations by consensus.

OR51V1 by HES1 expression — BLCA

Explore this box plot interactively →