HES1

Across TCGA patient cohorts, HES1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HES1-associated genes across cancer lineages are GAPDH, JNK_pT183_Y185, and MEK1. Each is linked with HES1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HES1-to-partner and partner-to-HES1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by HES1-low versus HES1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HES1→partner) and Y-score (partner→HES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.599	+3.169	.026	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.222	-3.446	.008	.005	3	1
UCEC	MEK1 →	+0.428	+2.321	.019	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.807	-2.308	<.001	.036	3	1
UCEC	Rab25 →	-0.732	-2.321	<.001	.035	3	1
UCEC	Rad50 →	-0.245	-2.321	.044	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GAPDH by HES1 expression — UCEC

Explore this box plot interactively →