HES1

Across TCGA cell cohorts, HES1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,662 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HES1-associated GO terms across cancer lineages are Comma-shaped body morphogenesis, Regulation of inner ear receptor cell differentiation, and Regulation of mechanoreceptor differentiation. Each is linked with HES1 in more than 18 cancer types. Because this analysis shows association rather than direction, both HES1-to-partner and partner-to-HES1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Comma-shaped body morphogenesis grouped by HES1-low versus HES1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HES1→partner) and Y-score (partner→HES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Comma-shaped body morphogenesis →	+1.461	+3.421	<.001	<.001	3	19
BLOOD_Leukemia	Regulation of inner ear receptor cell differentiation →	+1.822	+3.858	<.001	<.001	3	18
BLOOD_Leukemia	Regulation of mechanoreceptor differentiation →	+1.822	+3.858	<.001	<.001	3	18
LUNG_SCLC	Negative regulation of pro-B cell differentiation →	+1.107	+2.160	<.001	<.001	3	18
KIDNEY	Radial glial cell differentiation →	+0.160	+1.766	.001	<.001	3	17
LUNG_NSCLC_LUSC	Response to Aroclor 1254 →	+1.769	+2.235	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,662 associations by consensus.

Comma-shaped body morphogenesis by HES1 expression — BLOOD_Leukemia

Explore this box plot interactively →