HES1

Across TCGA cell cohorts, HES1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HES1-associated genes across cancer lineages are TAAR8, DEFB125, and OR4C12. Each is linked with HES1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HES1-to-partner and partner-to-HES1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAAR8 grouped by HES1-low versus HES1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HES1→partner) and Y-score (partner→HES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TAAR8 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	DEFB125 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	CROCC2 →	+0.284	+4.273	<.001	.002	3	1
LUNG_NSCLC_LUAD	GYPB →	+0.080	+3.544	.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

TAAR8 by HES1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →