HERPUD1

Across TCGA patient cohorts, HERPUD1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HERPUD1-associated genes across cancer lineages are MEK1, Notch1, and ATM. Each is linked with HERPUD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HERPUD1-to-partner and partner-to-HERPUD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by HERPUD1-low versus HERPUD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERPUD1→partner) and Y-score (partner→HERPUD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.488	+3.321	.005	.010	3	1
UCEC	Notch1 →	+0.192	+3.013	.004	.018	3	1
UCEC	ATM →	-0.523	-2.459	.017	.020	2	2
UCEC	EGFR_pY1068 →	-0.304	-3.584	.012	.002	2	1
UCEC	PCNA →	+0.231	+2.459	.027	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MEK1 by HERPUD1 expression — UCEC

Explore this box plot interactively →