HERPUD1

Across TCGA cell cohorts, HERPUD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,000 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HERPUD1-associated GO terms across cancer lineages are Endoplasmic reticulum unfolded protein response, Cellular response to unfolded protein, and Response to endoplasmic reticulum stress. Each is linked with HERPUD1 in more than 15 cancer types. Because this analysis shows association rather than direction, both HERPUD1-to-partner and partner-to-HERPUD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum unfolded protein response grouped by HERPUD1-low versus HERPUD1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HERPUD1→partner) and Y-score (partner→HERPUD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Endoplasmic reticulum unfolded protein response →	+0.114	+1.414	.001	<.001	3	16
BONE	Cellular response to unfolded protein →	+0.088	+1.390	<.001	<.001	3	16
PANCREAS	Response to endoplasmic reticulum stress →	+0.088	+1.586	.001	<.001	3	16
BONE	Regulation of translation initiation in response to endoplasmic reticulum stress →	+0.151	+1.623	<.001	<.001	3	16
CNS	Protein exit from endoplasmic reticulum →	+0.125	+1.374	<.001	<.001	3	15
BONE	Regulation of translation in response to endoplasmic reticulum stress →	+0.165	+1.321	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,000 associations by consensus.

Endoplasmic reticulum unfolded protein response by HERPUD1 expression — PANCREAS

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