HERPUD1

Across TCGA cell cohorts, HERPUD1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HERPUD1-associated genes across cancer lineages are RSPH6A, C6orf118, and PENK. Each is linked with HERPUD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HERPUD1-to-partner and partner-to-HERPUD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RSPH6A grouped by HERPUD1-low versus HERPUD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERPUD1→partner) and Y-score (partner→HERPUD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RSPH6A →	+0.125	+3.466	<.001	.005	3	1
LARGE_INTESTINE	C6orf118 →	+0.085	+3.115	.008	.004	3	1
LARGE_INTESTINE	PENK →	+0.434	+3.451	.001	.008	3	1
LARGE_INTESTINE	OR4A47 →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

RSPH6A by HERPUD1 expression — LARGE_INTESTINE

Explore this box plot interactively →