HERC6

Across TCGA pan-cancer cohorts, HERC6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HERC6 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher HERC6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HERC6 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

GBM, PDAC, and UCEC are the cancer types where HERC6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.203	0.594	.005	16	view →
PDAC	OS	Median	IV	0.472	0.962	.024	6	view →
UCEC	DFS	Median	II,III,IV	0.727	1.000	.044	2	view →
HNSC	DFS	Tertile	III,IV	1.000	0.910	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HERC6–GBM (DFS)

Open the GBM breakdown →