HERC6

Across TCGA patient cohorts, HERC6 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,841 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible HERC6-associated proteins across cancer lineages are DDX58, IFIT1, and IFIT3. Each is linked with HERC6 in more than 9 cancer types. Because this analysis shows association rather than direction, both HERC6-to-partner and partner-to-HERC6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HERC6 versus DDX58 in HNSC, with a Pearson correlation of 0.64.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC6→partner) and Y-score (partner→HERC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DDX58 →	+0.934	+1.472	<.001	<.001	3	10
HNSC	IFIT1 →	+1.285	+1.568	<.001	<.001	3	10
HNSC	IFIT3 →	+1.391	+1.571	<.001	<.001	3	10
HNSC	IFIT5 →	+0.645	+1.127	<.001	<.001	3	10
HNSC	IRF9 →	+0.515	+1.329	<.001	<.001	3	10
HNSC	ISG15 →	+1.238	+1.354	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,841 associations by consensus.

HERC6 vs DDX58 — HNSC

Explore this scatter interactively →