HERC6

Across TCGA patient cohorts, HERC6 protein abundance is significantly associated with the RNA expression of many other genes, with 7,810 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible HERC6-associated genes across cancer lineages are OAS3, OAS2, and IFIT3. Each is linked with HERC6 in more than 7 cancer types. Because this analysis shows association rather than direction, both HERC6-to-partner and partner-to-HERC6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HERC6 versus OAS3 in GBM, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC6→partner) and Y-score (partner→HERC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	OAS3 →	+1.444	+0.823	<.001	<.001	3	8
GBM	OAS2 →	+1.789	+1.041	<.001	<.001	3	8
HNSC	IFIT3 →	+2.114	+1.104	<.001	<.001	3	8
HNSC	IFI6 →	+2.083	+1.158	<.001	<.001	3	8
HNSC	RSAD2 →	+2.171	+1.241	<.001	<.001	3	8
HNSC	CMPK2 →	+1.788	+1.201	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,810 associations by consensus.

HERC6 vs OAS3 — GBM

Explore this scatter interactively →