HERC6

Across TCGA patient cohorts, HERC6 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HERC6-associated genes across cancer lineages are FASN, eEF2, and JNK2. Each is linked with HERC6 in more than 2 cancer types. Because this analysis shows association rather than direction, both HERC6-to-partner and partner-to-HERC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by HERC6-low versus HERC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC6→partner) and Y-score (partner→HERC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.309	+1.353	.004	.013	3	3
UCEC	eEF2 →	+0.197	+1.584	.043	.032	3	2
UCEC	JNK2 →	+0.238	+2.169	<.001	<.001	3	2
UCEC	Ku80 →	+0.267	+1.972	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.290	+2.807	.001	<.001	3	2
UCEC	Tuberin →	+0.308	+1.874	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

FASN by HERC6 expression — UCEC

Explore this box plot interactively →