HERC6

Across TCGA cell cohorts, HERC6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,697 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HERC6-associated GO terms across cancer lineages are Negative regulation of immune response, Defense response to virus, and Antiviral innate immune response. Each is linked with HERC6 in more than 17 cancer types. Because this analysis shows association rather than direction, both HERC6-to-partner and partner-to-HERC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of immune response grouped by HERC6-low versus HERC6-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC6→partner) and Y-score (partner→HERC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of immune response →	+0.078	+1.074	<.001	<.001	3	18
KIDNEY	Defense response to virus →	+0.107	+2.107	.001	<.001	3	18
KIDNEY	Antiviral innate immune response →	+0.107	+1.559	<.001	.001	3	17
BLOOD_Lymphoma	Cytoplasmic pattern recognition receptor signaling pathway →	+0.082	+1.525	<.001	.001	3	17
KIDNEY	Negative regulation of viral process →	+0.186	+1.665	.002	.003	3	17
BREAST	Intracellular receptor signaling pathway →	+0.056	+1.596	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,697 associations by consensus.

Negative regulation of immune response by HERC6 expression — BREAST

Explore this box plot interactively →