HERC6

Across TCGA cell cohorts, HERC6 mutation is significantly associated with the RNA expression of many other genes, with 898 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HERC6-associated genes across cancer lineages are ANKRD54, KIAA0930, and ST13. Each is linked with HERC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HERC6-to-partner and partner-to-HERC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD54 grouped by HERC6-low versus HERC6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC6→partner) and Y-score (partner→HERC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ANKRD54 →	+0.532	+3.451	.001	.002	3	1
LARGE_INTESTINE	KIAA0930 →	+0.501	+3.451	.006	.002	3	1
LARGE_INTESTINE	ST13 →	+0.533	+3.169	.003	.009	3	1
LARGE_INTESTINE	ZC3H7B →	+0.754	+3.364	.002	.002	3	1
LARGE_INTESTINE	TRMU →	+0.708	+3.364	<.001	.002	3	1
LARGE_INTESTINE	BRD1 →	+0.573	+3.169	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 898 associations by consensus.

ANKRD54 by HERC6 expression — LARGE_INTESTINE

Explore this box plot interactively →