HERC5

Across TCGA pan-cancer cohorts, HERC5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HERC5 data layer compared with 18 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HERC5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HERC5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where HERC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.307	0.645	<.001	24	view →
CCRCC	DFS	Median	II,III,IV	0.399	0.915	.040	3	view →
HNSC	DFS	Tertile	III,IV	1.000	0.922	.033	2	view →
GBM	OS	Quartile	All	0.946	0.655	.027	1	view →
LSCC	DFS	Quartile	II,III,IV	0.954	0.685	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HERC5–PDAC (OS)

Open the PDAC breakdown →