HERC5

Across TCGA patient cohorts, HERC5 protein abundance is significantly associated with the RNA expression of many other genes, with 8,349 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible HERC5-associated genes across cancer lineages are OAS2, STAT1, and IFIT3. Each is linked with HERC5 in more than 7 cancer types. Because this analysis shows association rather than direction, both HERC5-to-partner and partner-to-HERC5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HERC5 versus OAS2 in HNSC, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC5→partner) and Y-score (partner→HERC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OAS2 →	+1.428	+0.633	<.001	<.001	3	8
HNSC	STAT1 →	+1.470	+0.705	<.001	<.001	3	8
HNSC	IFIT3 →	+1.930	+0.543	<.001	<.001	3	8
HNSC	IFIT2 →	+1.629	+0.608	<.001	<.001	3	8
BRCA	IFI6 →	+1.670	+0.470	<.001	<.001	3	8
HNSC	RSAD2 →	+1.798	+0.718	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,349 associations by consensus.

HERC5 vs OAS2 — HNSC

Explore this scatter interactively →