HERC5

Across TCGA patient cohorts, HERC5 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HERC5-associated genes across cancer lineages are ERK2, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with HERC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both HERC5-to-partner and partner-to-HERC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by HERC5-low versus HERC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC5→partner) and Y-score (partner→HERC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.174	+1.584	.004	.032	3	3
COAD	Caspase-7-cleavedD198 →	+1.226	+2.186	<.001	.032	3	3
UCEC	14-3-3_beta →	-0.070	-1.558	.026	.032	3	2
UCEC	eIF4E →	+0.164	+2.432	.013	<.001	3	2
COAD	eIF4G →	+0.523	+3.321	.032	.009	3	2
COAD	FoxM1 →	+0.417	+2.820	.005	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ERK2 by HERC5 expression — UCEC

Explore this box plot interactively →