HERC5

Across TCGA cell cohorts, HERC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,739 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HERC5-associated GO terms across cancer lineages are Regulation of viral life cycle, Regulation of viral process, and Response to type I interferon. Each is linked with HERC5 in more than 12 cancer types. Because this analysis shows association rather than direction, both HERC5-to-partner and partner-to-HERC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of viral life cycle grouped by HERC5-low versus HERC5-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC5→partner) and Y-score (partner→HERC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of viral life cycle →	+0.104	+1.731	<.001	<.001	3	13
CNS	Regulation of viral process →	+0.107	+1.875	<.001	<.001	3	13
BREAST	Response to type I interferon →	+0.121	+1.721	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of viral genome replication →	+0.110	+1.367	<.001	<.001	3	12
BREAST	Negative regulation of viral genome replication →	+0.197	+2.328	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral process →	+0.141	+1.276	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,739 associations by consensus.

Regulation of viral life cycle by HERC5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →