HERC5

Across TCGA cell cohorts, HERC5 mutation is significantly associated with the RNA expression of many other genes, with 144 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HERC5-associated genes across cancer lineages are COX4I2, NLRP8, and SPINK8. Each is linked with HERC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HERC5-to-partner and partner-to-HERC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX4I2 grouped by HERC5-low versus HERC5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC5→partner) and Y-score (partner→HERC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	COX4I2 →	+0.095	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	NLRP8 →	+0.054	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	SPINK8 →	+0.438	+5.228	<.001	.005	3	1
LUNG_SCLC	GYPB →	+0.142	+3.762	.001	.003	3	1
BLOOD_Lymphoma	CCDC172 →	+0.646	+5.209	<.001	.005	3	1
LARGE_INTESTINE	CBY1 →	+0.644	+3.451	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 144 associations by consensus.

COX4I2 by HERC5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →