HERC4

Across TCGA pan-cancer cohorts, HERC4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HERC4 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher HERC4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HERC4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, UCEC, and COAD are the cancer types where HERC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.102	0.703	<.001	36	view →
UCEC	DFS	Median	All	0.935	0.622	.020	6	view →
COAD	DFS	Median	II,III,IV	0.189	0.648	.010	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HERC4–ESCA (OS)

Open the ESCA breakdown →