HERC4

Across TCGA pan-cancer cohorts, HERC4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HERC4 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HERC4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HERC4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

LUAD, UCEC, and LSCC are the cancer types where HERC4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	III,IV	0.310	0.911	.001	30	view →
UCEC	DFS	Quartile	All	1.000	0.826	.006	10	view →
LSCC	OS	Quartile	All	0.698	0.908	.017	5	view →
HNSC	DFS	Quartile	All	0.853	0.588	.022	5	view →
CCRCC	OS	Median	IV	0.150	0.785	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HERC4–LUAD (DFS)

Open the LUAD breakdown →