HERC4

Across TCGA patient cohorts, HERC4 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,588 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HERC4-associated proteins across cancer lineages are SLK, ANXA7, and KIFBP. Each is linked with HERC4 in more than 5 cancer types. Because this analysis shows association rather than direction, both HERC4-to-partner and partner-to-HERC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HERC4 versus SLK in HNSC, with a Pearson correlation of 0.23.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC4→partner) and Y-score (partner→HERC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLK →	+0.315	+0.371	<.001	.001	2	6
BRCA	ANXA7 →	+0.258	+0.412	<.001	<.001	3	5
GBM	KIFBP →	+0.265	+0.373	.001	<.001	3	4
GBM	CCDC6 →	+0.390	+0.358	<.001	<.001	3	4
COAD	ADO →	+0.320	+0.350	<.001	<.001	3	4
UCEC	SEC24C →	+0.182	+0.348	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,588 associations by consensus.

HERC4 vs SLK — HNSC

Explore this scatter interactively →