HERC4

Across TCGA patient cohorts, HERC4 protein abundance is significantly associated with the RNA expression of many other genes, with 13,442 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HERC4-associated genes across cancer lineages are RAD51AP1, TICRR, and CCDC150. Each is linked with HERC4 in more than 6 cancer types. Because this analysis shows association rather than direction, both HERC4-to-partner and partner-to-HERC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HERC4 versus RAD51AP1 in UCEC, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC4→partner) and Y-score (partner→HERC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51AP1 →	-1.162	-0.287	<.001	<.001	3	7
UCEC	TICRR →	-1.124	-0.275	<.001	<.001	3	7
UCEC	CCDC150 →	-0.871	-0.238	<.001	<.001	3	7
UCEC	KIF18A →	-1.037	-0.314	<.001	<.001	3	6
UCEC	CDCA5 →	-1.421	-0.301	<.001	<.001	3	6
GBM	XRCC2 →	-1.139	-0.192	<.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,442 associations by consensus.

HERC4 vs RAD51AP1 — UCEC

Explore this scatter interactively →