HERC4

Across TCGA patient cohorts, HERC4 mutation is significantly associated with the RNA expression of many other genes, with 3,574 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HERC4-associated genes across cancer lineages are CDC20, LRR1, and CDT1. Each is linked with HERC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both HERC4-to-partner and partner-to-HERC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDC20 grouped by HERC4-low versus HERC4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC4→partner) and Y-score (partner→HERC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDC20 →	+0.943	+2.537	<.001	.008	3	3
UCEC	LRR1 →	+0.570	+1.999	<.001	<.001	3	3
UCEC	CDT1 →	+0.618	+2.032	<.001	<.001	3	3
UCEC	CHAF1A →	+0.641	+2.294	<.001	<.001	3	3
UCEC	CKAP2L →	+0.524	+1.765	.002	<.001	3	3
UCEC	LMNB2 →	+0.553	+2.555	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,574 associations by consensus.

CDC20 by HERC4 expression — SKCM

Explore this box plot interactively →