HERC4

Across TCGA patient cohorts, HERC4 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HERC4-associated genes across cancer lineages are Notch1, Akt_pS473, and p27_pT198. Each is linked with HERC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HERC4-to-partner and partner-to-HERC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by HERC4-low versus HERC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC4→partner) and Y-score (partner→HERC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.141	+1.598	.002	.040	3	2
UCEC	Akt_pS473 →	+0.595	+1.502	.011	.027	3	2
UCEC	p27_pT198 →	+0.078	+2.115	.026	.017	3	2
UCEC	Akt_pT308 →	+0.537	+2.700	.009	.005	3	2
UCEC	TFRC →	+0.368	+1.874	.035	.049	3	2
UCEC	ATM →	-0.536	-2.687	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Notch1 by HERC4 expression — UCEC

Explore this box plot interactively →