HERC4

Across TCGA cell cohorts, HERC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,938 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible HERC4-associated GO terms across cancer lineages are Positive regulation of focal adhesion assembly, Regulation of hippo signaling, and Cellular response to environmental stimulus. Each is linked with HERC4 in more than 13 cancer types. Because this analysis shows association rather than direction, both HERC4-to-partner and partner-to-HERC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of focal adhesion assembly grouped by HERC4-low versus HERC4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC4→partner) and Y-score (partner→HERC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of focal adhesion assembly →	+0.160	+1.499	<.001	<.001	3	14
LIVER	Regulation of hippo signaling →	+0.095	+1.043	.005	.007	3	13
LARGE_INTESTINE	Cellular response to environmental stimulus →	+0.048	+0.849	<.001	<.001	3	12
STOMACH	Positive regulation of plasma membrane repair →	+0.183	+1.059	.001	<.001	3	12
LUNG_NSCLC_LUSC	Regulation of cell-matrix adhesion →	+0.106	+1.689	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of cytoskeleton organization →	+0.082	+1.714	.005	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,938 associations by consensus.

Positive regulation of focal adhesion assembly by HERC4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →