HERC3

Across TCGA pan-cancer cohorts, HERC3 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HERC3 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HERC3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HERC3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

KIRC, UCEC, and LUAD are the cancer types where HERC3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	II,III,IV	0.054	0.806	<.001	48	view →
UCEC	DFS	Median	All	0.948	0.611	.002	34	view →
LUAD	OS	Median	All	0.068	0.788	<.001	23	view →
SARC	DFS	Median	All	0.024	0.611	<.001	6	view →
KIRP	OS	Median	All	0.105	0.688	.004	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUSC	DFS	Median	All	0.881	0.370	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HERC3–KIRC (OS)

Open the KIRC breakdown →