HERC3

Across TCGA patient cohorts, HERC3 protein abundance is significantly associated with the RNA expression of many other genes, with 413 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HERC3-associated genes across cancer lineages are PRSS33, GLIS3, and MANSC1. Each is linked with HERC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HERC3-to-partner and partner-to-HERC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HERC3 versus PRSS33 in LUAD, with a Pearson correlation of 0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC3→partner) and Y-score (partner→HERC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PRSS33 →	+0.207	+0.497	<.001	.002	3	1
LUAD	GLIS3 →	-1.473	-0.656	.001	.003	3	1
LUAD	MANSC1 →	+1.047	+0.497	<.001	.002	3	1
LUAD	CHPT1 →	+1.661	+0.497	.001	.002	3	1
LUAD	SMIM8 →	-0.756	-0.656	.002	.003	3	1
LUAD	CUL9 →	-0.609	-0.656	.009	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 413 associations by consensus.

HERC3 vs PRSS33 — LUAD

Explore this scatter interactively →