HERC3

Across TCGA patient cohorts, HERC3 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HERC3-associated genes across cancer lineages are ACC1, Caspase-7-cleavedD198, and Ku80. Each is linked with HERC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HERC3-to-partner and partner-to-HERC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by HERC3-low versus HERC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC3→partner) and Y-score (partner→HERC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.234	+1.054	.023	.029	3	3
UCEC	Caspase-7-cleavedD198 →	+0.474	+1.341	.004	.017	3	3
SKCM	Ku80 →	+0.292	+2.321	.033	.035	3	2
SKCM	DJ-1 →	+0.305	+3.000	<.001	.034	3	2
UCEC	MEK1 →	+0.297	+1.584	.004	.001	3	2
UCEC	NF-kB-p65_pS536 →	-0.286	-1.807	.027	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ACC1 by HERC3 expression — UCEC

Explore this box plot interactively →