HERC3

Across TCGA cell cohorts, HERC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,901 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HERC3-associated GO terms across cancer lineages are Positive regulation of type 2 mitophagy, Regulation of Golgi inheritance, and Regulation of type 2 mitophagy. Each is linked with HERC3 in more than 11 cancer types. Because this analysis shows association rather than direction, both HERC3-to-partner and partner-to-HERC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of type 2 mitophagy grouped by HERC3-low versus HERC3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC3→partner) and Y-score (partner→HERC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of type 2 mitophagy →	+0.138	+1.532	<.001	.004	3	12
CNS	Regulation of Golgi inheritance →	+0.135	+0.931	<.001	<.001	3	12
URINARY_TRACT	Regulation of type 2 mitophagy →	+0.144	+1.392	<.001	.002	3	11
SKIN	Phosphatidylinositol metabolic process →	+0.040	+0.695	.002	<.001	3	11
SOFT_TISSUE	Caveolin-mediated endocytosis →	+0.162	+0.961	<.001	.001	3	11
OESOPHAGUS	Positive regulation of endoplasmic reticulum tubular network organization →	+0.100	+1.302	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,901 associations by consensus.

Positive regulation of type 2 mitophagy by HERC3 expression — URINARY_TRACT

Explore this box plot interactively →