HERC2P8

Across TCGA pan-cancer cohorts, HERC2P8 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated HERC2P8 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher HERC2P8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HERC2P8 expression acts as an unfavorable survival marker, although some lineages such as READ and ESCA show a favorable association.

UVM, COAD, and ACC are the cancer types where HERC2P8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.302	0.625	.002	55	view →
COAD	DFS	Tertile	All	0.356	0.579	.006	39	view →
ACC	OS	Median	All	0.678	0.859	.005	37	view →
CHOL	DFS	Median	All	0.257	0.631	.022	34	view →
KICH	OS	Median	III,IV	0.369	0.866	.006	24	view →
READ	OS	Tertile	All	0.838	0.554	.017	24	view →
LIHC	DFS	Tertile	All	0.442	0.586	.004	23	view →
ESCA	OS	Median	IV	0.743	0.290	.013	18	view →
PAAD	DFS	Median	All	0.366	0.148	.016	15	view →
OV	OS	Median	IV	0.516	0.273	.004	14	view →
LUSC	DFS	Median	All	0.308	0.577	.010	14	view →
LUAD	DFS	Median	IV	0.699	1.000	.018	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

HERC2P8–UVM (DFS)

Open the UVM breakdown →