HERC2P7

Across TCGA pan-cancer cohorts, HERC2P7 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of HERC2P7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HERC2P7 RNA is repressed in tumor relative to normal tissue. In most cancer types HERC2P7 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

KIRC, KICH, and PRAD are the cancer types where HERC2P7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HERC2P7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	−0.019	.011	4	view →
KICH	Female	III,IV	+0.090	.004	2	view →
PRAD	All	All	+0.034	.047	2	view →
LUSC	All	All	+0.052	.012	1	view →
STAD	Male	All	+0.044	.045	1	view →
LUAD	All	All	+0.036	.049	1	view →
HNSC	All	III,IV	+0.017	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

HERC2P7–KIRC

Open the KIRC breakdown →