HERC2P3

Across TCGA pan-cancer cohorts, HERC2P3 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated HERC2P3 data layer compared with 18 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher HERC2P3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HERC2P3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

ESCA, SKCM, and UCEC are the cancer types where HERC2P3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	IV	0.095	0.512	.008	26	view →
SKCM	OS	Median	II,III,IV	0.918	0.720	.014	12	view →
UCEC	DFS	Median	All	0.962	0.622	.016	8	view →
BLCA	OS	Median	III,IV	0.413	0.688	.010	6	view →
PRAD	DFS	Median	All	0.086	0.776	<.001	6	view →
LIHC	DFS	Median	All	0.229	0.560	.009	6	view →
LGG	OS	Median	All	0.299	0.801	.008	3	view →
LUSC	DFS	Median	All	0.322	0.711	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

HERC2P3–ESCA (OS)

Open the ESCA breakdown →