HERC2P2

Across TCGA pan-cancer cohorts, HERC2P2 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HERC2P2 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HERC2P2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HERC2P2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM, UCEC, and SARC are the cancer types where HERC2P2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	III,IV	0.125	0.601	.001	11	view →
UCEC	DFS	Median	All	0.938	0.616	.012	8	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
COAD	OS	Median	All	0.603	0.872	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HERC2P2–SKCM (DFS)

Open the SKCM breakdown →