HERC2P2

Across TCGA patient cohorts, HERC2P2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HERC2P2-associated genes across cancer lineages are Ku80, ASNS, and p62 Lck ligand. Each is linked with HERC2P2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HERC2P2-to-partner and partner-to-HERC2P2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by HERC2P2-low versus HERC2P2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC2P2→partner) and Y-score (partner→HERC2P2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.240	+1.790	.001	.001	3	3
UCEC	ASNS →	+0.434	+2.415	<.001	.002	3	3
UCEC	p62 Lck ligand →	+0.472	+2.378	<.001	<.001	3	2
UCEC	p70-S6K →	+0.143	+1.550	.019	.004	3	2
UCEC	ATM →	-0.556	-2.794	<.001	.002	3	2
UCEC	Caspase-8 →	-0.247	-4.221	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Ku80 by HERC2P2 expression — UCEC

Explore this box plot interactively →