HERC2

Across TCGA patient cohorts, HERC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,655 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HERC2-associated proteins across cancer lineages are RTF1, HNRNPLL, and ILF2. Each is linked with HERC2 in more than 5 cancer types. Because this analysis shows association rather than direction, both HERC2-to-partner and partner-to-HERC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HERC2 versus RTF1 in GBM, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC2→partner) and Y-score (partner→HERC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RTF1 →	+0.296	+0.307	<.001	<.001	3	6
GBM	HNRNPLL →	+0.283	+0.377	<.001	<.001	3	5
GBM	ILF2 →	+0.234	+0.293	.001	<.001	3	5
UCEC	UBE2J1_S251 →	-1.038	-0.622	<.001	<.001	3	4
GBM	ADNP →	+0.364	+0.269	<.001	<.001	3	4
GBM	CTDSPL2 →	+0.414	+0.308	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,655 associations by consensus.

HERC2 vs RTF1 — GBM

Explore this scatter interactively →