HERC2

Across TCGA patient cohorts, HERC2 protein abundance is significantly associated with the RNA expression of many other genes, with 8,479 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HERC2-associated genes across cancer lineages are EIF5A, NAA38, and DOCK8. Each is linked with HERC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both HERC2-to-partner and partner-to-HERC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HERC2 versus EIF5A in LUAD, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC2→partner) and Y-score (partner→HERC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EIF5A →	+0.497	+0.159	<.001	<.001	3	5
COAD	NAA38 →	+0.579	+0.323	.003	.005	3	4
LSCC	DOCK8 →	-0.724	-0.214	<.001	<.001	3	4
LSCC	SLC25A11 →	+0.388	+0.188	<.001	<.001	3	4
BRCA	CDCA3 →	+0.918	+0.204	<.001	<.001	3	4
LUAD	GINS2 →	+0.598	+0.105	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,479 associations by consensus.

HERC2 vs EIF5A — LUAD

Explore this scatter interactively →