HERC2

Across TCGA patient cohorts, HERC2 mutation is significantly associated with the total protein of many other genes, with 114 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HERC2-associated genes across cancer lineages are Cyclin-B1, ASNS, and PCNA. Each is linked with HERC2 in more than 5 cancer types. Because this analysis shows association rather than direction, both HERC2-to-partner and partner-to-HERC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by HERC2-low versus HERC2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC2→partner) and Y-score (partner→HERC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-B1 →	+0.606	+2.415	<.001	.003	3	6
LUAD	ASNS →	+0.616	+1.514	<.001	.014	3	6
STAD	PCNA →	+0.285	+3.459	.002	.004	3	5
COAD	Caspase-7-cleavedD198 →	+1.221	+2.108	<.001	<.001	3	5
BRCA	Cyclin-E1 →	+0.275	+2.820	.039	.036	3	4
LUAD	FoxM1 →	+0.280	+2.492	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

Cyclin-B1 by HERC2 expression — LUAD

Explore this box plot interactively →