HEPHL1

Across TCGA patient cohorts, HEPHL1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,101 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HEPHL1-associated genes across cancer lineages are SCML2, JADE3, and ARMCX3. Each is linked with HEPHL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HEPHL1-to-partner and partner-to-HEPHL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HEPHL1 versus SCML2 in LSCC, with a Pearson correlation of -0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEPHL1→partner) and Y-score (partner→HEPHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SCML2 →	-1.888	-1.044	.001	.002	3	2
LSCC	JADE3 →	-0.633	-0.915	.004	.002	3	2
LSCC	ARMCX3 →	-1.008	-0.921	.001	.004	3	2
LSCC	MEFV →	+1.204	+1.072	<.001	.006	3	2
LSCC	MYEF2 →	-1.057	-0.990	<.001	<.001	3	2
LSCC	RLN2 →	-0.921	-0.734	.009	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,101 associations by consensus.

HEPHL1 vs SCML2 — LSCC

Explore this scatter interactively →