HEPHL1

Across TCGA patient cohorts, HEPHL1 mutation is significantly associated with the RNA expression of many other genes, with 6,452 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEPHL1-associated genes across cancer lineages are OIP5, GPI, and RFC5. Each is linked with HEPHL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HEPHL1-to-partner and partner-to-HEPHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OIP5 grouped by HEPHL1-low versus HEPHL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEPHL1→partner) and Y-score (partner→HEPHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OIP5 →	+0.806	+2.057	<.001	<.001	3	5
UCEC	GPI →	+0.479	+1.873	<.001	<.001	3	5
UCEC	RFC5 →	+0.488	+1.696	<.001	<.001	3	5
UCEC	DHFR →	+0.704	+1.700	<.001	<.001	3	5
UCEC	MAPKAPK5-AS1 →	+0.376	+2.069	<.001	<.001	3	5
UCEC	ZNF367 →	+0.698	+1.857	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,452 associations by consensus.

OIP5 by HEPHL1 expression — UCEC

Explore this box plot interactively →