HEPHL1

Across TCGA cell cohorts, HEPHL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,294 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible HEPHL1-associated GO terms across cancer lineages are Negative regulation of response to endoplasmic reticulum stress, Negative regulation of intrinsic apoptotic signaling pathway, and Negative regulation of response to biotic stimulus. Each is linked with HEPHL1 in more than 6 cancer types. Because this analysis shows association rather than direction, both HEPHL1-to-partner and partner-to-HEPHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of response to endoplasmic reticulum stress grouped by HEPHL1-low versus HEPHL1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HEPHL1→partner) and Y-score (partner→HEPHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of response to endoplasmic reticulum stress →	+0.049	+0.822	.003	.002	3	7
LARGE_INTESTINE	Negative regulation of intrinsic apoptotic signaling pathway →	+0.058	+0.698	<.001	.002	3	6
KIDNEY	Negative regulation of response to biotic stimulus →	+0.061	+0.042	.005	.008	3	6
CNS	Steroid catabolic process →	-0.098	-0.238	<.001	.004	3	6
KIDNEY	Regulation of syncytium formation by plasma membrane fusion →	+0.082	+0.057	.002	<.001	3	6
BLOOD_Myeloma	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.153	+0.087	.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,294 associations by consensus.

Negative regulation of response to endoplasmic reticulum stress by HEPHL1 expression — LARGE_INTESTINE

Explore this box plot interactively →