HEPHL1

Across TCGA cell cohorts, HEPHL1 mutation is significantly associated with the RNA expression of many other genes, with 110 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEPHL1-associated genes across cancer lineages are KAAG1, MPEG1, and CST9. Each is linked with HEPHL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HEPHL1-to-partner and partner-to-HEPHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KAAG1 grouped by HEPHL1-low versus HEPHL1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEPHL1→partner) and Y-score (partner→HEPHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KAAG1 →	+0.059	+3.285	.002	.009	3	2
BLOOD_Myeloma	MPEG1 →	+0.143	+3.716	.004	.005	3	2
CNS	CST9 →	+0.042	+4.981	<.001	.008	3	2
LUNG_NSCLC_LUAD	PRAMEF18 →	+0.003	+2.887	<.001	.009	3	2
BLOOD_Myeloma	CGNL1 →	+0.993	+3.662	.005	.005	3	1
BLOOD_Myeloma	MYBPC3 →	+0.023	+4.247	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

KAAG1 by HEPHL1 expression — BLOOD_Myeloma

Explore this box plot interactively →