HEPHL1

Across TCGA cell cohorts, HEPHL1 mutation is significantly associated with the mutation status of many other genes, with 1,189 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEPHL1-associated genes across cancer lineages are KIF18B, FANCA, and FLT1. Each is linked with HEPHL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HEPHL1-to-partner and partner-to-HEPHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF18B grouped by HEPHL1-low versus HEPHL1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEPHL1→partner) and Y-score (partner→HEPHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KIF18B →	+5.108	+3.847	.001	.001	1	5
BLOOD_Lymphoma	FANCA →	+3.201	+3.337	.001	.001	1	4
BLOOD_Lymphoma	FLT1 →	+3.201	+3.337	.001	.001	1	4
LARGE_INTESTINE	CAND2 →	+1.819	+2.029	.005	.005	1	4
URINARY_TRACT	FMN1 →	+4.307	+3.672	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	TRPS1 →	+4.392	+4.954	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,189 associations by consensus.

KIF18B by HEPHL1 expression — BLOOD_Lymphoma

Explore this box plot interactively →